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AZ7550 hydrochloride
AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
Catalog No. T13564LCas No. 2309762-40-9
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Purity:97.07%
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AZ7550 hydrochloride
Catalog No. T13564LAlias AZ7550 hydrochloride (1421373-99-0 free base)Cas No. 2309762-40-9
AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $126 | In Stock | |
| 5 mg | $257 | In Stock | |
| 10 mg | $397 | In Stock | |
| 25 mg | $663 | In Stock | |
| 50 mg | $945 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM). |
| Targets&IC50 | FLT4:1784 nM , IGF-1R:1.6 μM , MLK1:88 nM , ERB4:195 nM , TEC:1317 nM , BLK:977 nM , Ack1:156 nM , INSR:1256 nM , ALK:420 nM , Brk:843 nM , MNK2:228 nM , FLT3:302 nM , FAK:995 nM , FES:449 nM , PYK2:2288 nM , IRR:840 nM |
| In vitro | AZ7550 (Compound 28) inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo (IC50s: 45, 26, and 786 nM). AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 (GI50s: 19, 15, and 537 nM). |
| Alias | AZ7550 hydrochloride (1421373-99-0 free base) |
| Molecular Weight | 522.04 |
| Formula | C27H32ClN7O2 |
| Cas No. | 2309762-40-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
| Solubility Information | DMSO: 1.5 mg/mL (2.8 mM), Sonication and heating are recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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